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TRIF agonist AV-C

  Cat. No.:  DC20571   Featured
Chemical Structure
620589-62-0
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More than 5000 active chemicals with high quality for research!
Field of application
TRIF agonist AV-C is a novel TRIF pathway agonist that activates innate and interferon-associated responses, strongly inhibits replication of ZIKV, CHIKV, and DENV (IC90~5 uM).
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 620589-62-0
Chemical Name: 1-(2-fluorophenyl)-2-(5-isopropyl-1,3,4-thiadiazol-2-yl)-1,2-dihydrochromeno[2,3-c]pyrrole-3,9-dione
SMILES: CC(C)C1=NN=C(S1)N2C(C3=C(C2=O)OC4=CC=CC=C4C3=O)C5=CC=CC=C5F
Formula: C22H16FN3O3S
M.Wt: 421.446
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: TRIF agonist AV-C is a novel TRIF pathway agonist that activates innate and interferon-associated responses, strongly inhibits replication of ZIKV, CHIKV, and DENV (IC90~5 uM); activates IFNAR-mediated transcription and translation of antiviral effector genes, AV-C-mediated, IRF3-dependent innate activation occurs independently of adaptor proteins IPS-1/MAVS and STING but requires TRIF.
References: References 1. Pryke KM, et al. MBio. 2017 May 2;8(3). pii: e00452-17. View Related Products by Target Other Targets
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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