AKI-603|AKI603|CAS 1432515-73-5|DC Chemicals

Cas No.:	1432515-73-5
Chemical Name:	N4-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-1-yl)-N2-(4-nitrophenyl)pyrimidine-2,4-diamine
Synonyms:	AKI603;AKI-603;AKI 603
SMILES:	CC1=CC(=NN1)NC2=CC(=NC(=N2)NC3=CC=C(C=C3)[N+](=O)[O-])N4CCN(CC4)C
Formula:	C₁₉H₂₃N₉O₂
M.Wt:	409.454
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	1. Zheng FM, et al. Mol Cancer Ther. 2014 Aug;13(8):1991-2003. 2. Long ZJ, et al. Int J Oncol. 2015;46(6):2488-96. 3. Wang LX, et al. Sci Rep. 2016 Nov 8;6:35533.

Description:

A novel small molecule Aurora A kinase inhibitor with IC50 of 12.3 nM, also inhibits Aurora B kinase activity to a less extent; disrupts normal spindle structure, and induces cell-cycle arrest; suppresses stem cell properties in breast cancer cells, and also suppresses the expression of self-renewal genes (β-catenin, c-Myc, Sox2, and Oct4); reduces xenograft tumor growth after intragastric administration.

References:

References 1. Zheng FM, et al. Mol Cancer Ther. 2014 Aug;13(8):1991-2003. 2. Long ZJ, et al. Int J Oncol. 2015;46(6):2488-96. 3. Wang LX, et al. Sci Rep. 2016 Nov 8;6:35533. View Related Products by Target Aurora Kinase

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

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