(-) BI97D6 |CAS 1256724-10-3|DC Chemicals

Cas No.:	1256724-10-3
Chemical Name:	5,5'-dibenzyl-6,6',7,7'-tetrahydroxy-3,3'-dimethyl-[2,2'-binaphthalene]-1,1',4,4'-tetraone
Synonyms:	BI97D6
Formula:	C₃₆H₂₆O₈
M.Wt:	586.596
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

(-) BI97D6 (BI112D1) is a potent, pan-active inhibitor of Bcl-2 family proteins with IC50 of 76, 31, 25, and 122 nM for Bcl-xL, Bcl-2, Mcl-1, and Bfl-1, respectively; effectively inhibits cell growth in the PC-3 human prostate cancer and H23 human lung cancer cell lines with EC50 of 0.22 and 0.14 uM, respectively; effectively induces apoptosis in the BP3 human lymphoma cell line; displays in vivo efficacy in a prostate cancer xenograft model in mice; also overcomes ABT-737 resistance in AML, kills AML leukemia stem/progenitor cells while largely sparing normal hematopoietic stem/progenitor cells.

MSDS

COA

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2018-0101

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