CK-37|ChoK-α inhibitor CK37|CAS 1001478-90-5

Cas No.:	1001478-90-5
Chemical Name:	N-(3,5-dimethylphenyl)-2-[[5-(4-ethylphenyl)-1H-1,2,4-triazol-3-yl]sulfanyl] acetamide
Synonyms:	ChoK-α inhibitor CK37;CK 37;CK-37
SMILES:	C(NC1=CC(C)=CC(C)=C1)(=O)CSC1N=C(C2=CC=C(CC)C=C2)NN=1
Formula:	C₂₀H₂₂N₄Os
M.Wt:	366.483
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

A potent, specific, competitive inhibitor of choline kinase-α (Chok-α) by targeting the choline binding site; significantly increases LC3II expression in MCF-7 and MCF-7/TAM cells, increases the size and number of autophagosome, causes MCF-7 and MCF-7/TAM cells to a slight increase in p62; suppresses MAPK and PI3K/AKT signaling, disrupts actin cytoskeletal organization, and reduces plasma membrane ruffling; significantly decreases tumor growth in a lung tumor xenograft mouse model, suppresses tumor phosphocholine, and diminishes activating phosphorylations of ERK and AKT in vivo.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

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