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NCGC00379308

  Cat. No.:  DC20939   Featured
Chemical Structure
662164-09-2
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More than 5000 active chemicals with high quality for research!
Field of application
A potent, functionally selective TSH receptor (TSHR) positive allosteric modulator with EC50 of 11.6 uM (β-Arr 1 translocation).
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 662164-09-2
Chemical Name: N-(1-phenylethyl)-2-(1-piperazinyl)-4-quinazolinamine
Synonyms: D3-βArr;NCGC-00379308;NCGC 00379308
SMILES: C1(C(NC2C3C(=CC=CC=3)N=C(N3CCNCC3)N=2)C)C=CC=CC=1
Formula: C20H23N5
M.Wt: 333.439
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: D3-βArr is a positive allosteric modulator for thyrotropin receptor (TSHR), which initiates translocation of β-Arr 1 by direct TSHR activation and potentiates TSH-mediated preosteoblast differentiation in vitro[1].
Target: Thyrotropin receptor (TSHR)[1]
References: [1]. Neumann S, et al. Discovery of a Positive Allosteric Modulator of the Thyrotropin Receptor: Potentiation of Thyrotropin-Mediated Preosteoblast Differentiation In Vitro. J Pharmacol Exp Ther. 2018 Jan;364(1):38-45.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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