Indisulam|CAS 165668-41-7|DC Chemicals

Cas No.:	165668-41-7
Chemical Name:	Indisulam
Synonyms:	Indisulam;N-(3-Chloro-1H-indol-7-yl)-1,4-benzenedisulfonamide;4-N-(3-chloro-1H-indol-7-yl)benzene-1,4-disulfonamide;1,4-Benzenedisulfonamide,N-(3-chloro-1H-indol-7-yl);E7070;Indisulam (IND);N-(3-chloro-1H-indol-7-yl)benzene-1,4-disulfonamide;N-(3-chloro-1H-indol-7-yl)-4-sulfamoylbenzenesulfonamide;N1-(3-Chloro-1H-indol-7-yl)-1,4-benzenedisulfonamide;E-7070;ER-35744;IndisulaM (E7070);IndisulaM (E7070) (ER-35744);N1-(3-Chloro-1H-indol-7-yl)benzene-1,4-disulfonamide;1,4-Benzenedisulfonamide, N-(3-chloro-1H-indol-7-yl)-;E 7070;WJ98J3NM90;N-(3-Chloro-1H-indol-7-yl)benzene-1,4disulfonamide;Indisulam (USAN/INN);N-(3-chl;INDISULAM;CS-0007710;FT-0740093;A904802;EF6;UNII-WJ98J3NM90;INDISULAM [WHO-DD];SB16544;indisulam (e7070);1-N-(3-chloro-1H-indol-7-yl)benzene-1,4-disulfonamide;indisulamum;INDISULAM [INN];Indisulam [USAN:INN:BAN];C14H12ClN3O4S2;HY-13650;1,4-BENZENEDISULFONAMIDE, N-(3-CHLORO-1H-INDOL-7-YL);165668-41-7;N(1)-(3-chloro-1H-indol-7-yl)benzene-1,4-disulfonamide;INDISULAM [USAN];C73201;Z2724205552;DB06370;1,4-Benzenedisulfonamide, N1-(3-chloro-1H-indol-7-yl)-;NS00068354;s9742;EN300-7378250;CHEMBL77517;N1-(3-chloro-1H-indol-7-yl)benzene-1,4-disulfonamide;GTPL7046;AKOS022181456;D04522;BCP06110;AS-69532;BDBM10890;CHEBI:145431;SCHEMBL91389;Q27078056;Indisulam, >=98% (HPLC);DTXSID50168008;n-(3-chloro-1h-indol-7-yl)-4-sulfamoylbenzenesulfonamide;INDISULAM [MI];AC-36646;N~1~-(3-chloro-1H-indol-7-yl)benzene-1,4-disulfonamide;N-(3-chloro-7-indolyl)-1,4-benzenedisulphonamide
SMILES:	ClC1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2N([H])S(C1C([H])=C([H])C(=C([H])C=1[H])S(N([H])[H])(=O)=O)(=O)=O
Formula:	C₁₄H₁₂ClN₃O₄S₂
M.Wt:	385.8458
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Indisulam (E7070) is potent, sulfonamide, cell-cycle inhibitor that possesses antiproliferative activities, causes decrease in the S phase fraction along with G1 and/or G2 accumulation in various cancer cell lines; causes blockade in the G1/S transition through inhibition of the activation of both cyclin-dependent kinase 2 and cyclin E, shows activity in multiple tumor types, most prominently in colon and lung cancer.Breast CancerPhase 2 Discontinued

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
DC60864	D927 (DS11252927)	D927 is a molecular glue and promotes glucose uptake in the absence of insulin. D927 also increases the affinity of RAS binding to PI3Kα by ~500-fold. In vivo, D927 mimicks the effects of insulin and rapidly lowers blood glucose concentrations.
DC60863	D223 (DS02312223)	D223 is a molecular glue and promotes glucose uptake in the absence of insulin. D223 also increases the affinity of RAS binding to PI3Kα by ~500-fold.
DC60858	LC-04-045	LC-04-045 is a leading NEK7 molecular glue degrader with DC50 of 7 nM and Dmax of 90 % in MOLT-4 cells. LC-04-045 displays high selectivity for NEK7 across the proteome.
DC60852	PVTX-405	PVTX-405 is a potent, effective, highly selective, and orally efficacious IKZF2 molecular glue degrader with DC50 of 0.7 nM. PVTX-405 in combination with anti-PD1 or anti-LAG3 significantly increases animal survival compared to anti-PD1 or anti-LAG3 alone.
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DC67413	MRT-23227
DC67412	MRT-3486	MRT-3486 (Compound 5) is a cereblon-based NEK7 molecular glue degrader. MRT-3486 can be used for autoinflammatory diseases research.
DC67411	MRT-7612
DC67410	MRT-10350
DC67407	IKZF1-degrader-1	IKZF1-degrader-1 (Compound 9-B) is a highly potent molecular glue that achieves sub-nanomolar degradation of IKZF1 (DC50 = 0.134 nM), demonstrating significant therapeutic potential for targeting IKZF1-dependent malignancies.