GATA4-IN-3|CAS 544681-96-1|DC Chemicals

Cas No.:	544681-96-1
Chemical Name:	GATA4-NKX2-5-IN-1
Synonyms:	4-Isoxazolecarboxamide, N-[4-(diethylamino)phenyl]-5-methyl-3-phenyl-;GATA4-IN-3 (GATA4 inhibitor 3);GATA4-IN-3;N-[4-(diethylamino)phenyl]-5-methyl-3-phenyl-4-isoxazolecarboxamide;GATA4-NKX2-5-IN-1;N-[4-(Diethylamino)phenyl]-5-methyl-3-phenyl-1,2-oxazole-4-carboxamide;3i-1000;Z28150190;DA-53521;CHEMBL361366;AKOS001120472;EU-0016645;HY-103484;TS-07813;G13198;BDBM50161047;5-Methyl-3-phenyl-isoxazole-4-carboxylic acid (4-diethylamino-phenyl)-amide;544681-96-1;N-[4-(diethylamino)phenyl]-5-methyl-3-phenylisoxazole-4-carboxamide;SCHEMBL19995013;CS-0027989;EN300-18117205;TQR1120;BCP25925;AK-968/15612676;Oprea1_612719;CCG-325450;STK437853;EX-A4534;N-[4-(diethylamino)phenyl]-5-methyl-3-phenyl-1,2-oxazole-4-carboxamide
SMILES:	CC1=C(C(NC2=CC=C(N(CC)CC)C=C2)=O)C(C3=CC=CC=C3)=NO1
Formula:	C₂₁H₂₃N₃O₂
M.Wt:	349.426
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

A novel small molecule that inhibits GATA4/NKX2-5 transcriptional synergy with IC50 of 3 uM, with no activity on the protein kinases involved in the regulation of GATA4 phosphorylation; also inhibits the ET-1-stimulated BNP gene expression, and inhibits hypertrophic growth in a cardiomyocyte hypertrophy model, without effect on apoptotic cell death.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
DC31074	Isopropyl myristate	Isopropyl myristate is the ester of isopropyl alcohol and myristic acid.
DC75868	AZ14133346	AZ14133346 (compound 36) is a potent and selective inhibitor of EGFR Exon20 insertions, with the IC50 of 85 nM. AZ14133346 plays an important role in cancer research.
DC75865	TI17	TI17 represents a novel class of targeted anticancer agents that specifically disrupt DNA damage repair mechanisms in malignant cells.
DC75816	Nisoxetine	Nisoxetine acts as a highly selective and potent noradrenaline transporter (NET) antagonist, exhibiting a binding affinity (Kd) of 0.76 nM. In addition to its antidepressant properties, nisoxetine functions as a local anesthetic by inhibiting voltage-gated sodium channels. This dual pharmacological activity makes it a compound of interest for both neurological and pain management research.
DC75641	GENZ-644282 TFA salt	Genz-644282, also known as SAR402674, is a non-camptothecin inhibitor of topoisomerase I with potential antineoplastic activity. Topoisomerase I inhibitor Genz-644282 binds to and inhibits the enzyme topoisomerase I, which may result in the inhibition of repair of single-strand DNA breaks, DNA replication, and tumor cell growth in susceptible tumor cell populations.
DC75325	PSMA-617 TFA	PSMA-617, also know as vipivotide tetraxetan, is a ligand used to make 177Lu-PSMA-617, which is a radioactive molecule to fight cancer. PSMA617 possesses a small peptide, which was designed to target prostate-specific membrane antigen (PSMA). PSMA617 demonstrates high radiolytic stability for at least 72 h. PSMA617 has high inhibition potency (equilibrium dissociation constant Ki=2.34±2.94 nM on LNCaP; Ki=0.37±0.21 nM enzymatically determined). 177 Lu-PSMA-617 offers a potential additional life-prolonging treatment option for men with mCRPC.
DC75202	Fosaprepitant free acid	Fosaprepitant, also known as MK0517, is an antiemetic drug, administered intravenously. It is a prodrug of aprepitant. Fosaprepitant was developed by Merck & Co. and was approved. It is a prodrug of Aprepitant. It aids in the prevention of acute and delayed nausea and vomiting associated with chemotherapy treatment. Fosaprepitant is a weak inhibitor of CYP3A4, and aprepitant, the active moiety, is a substrate, inhibitor, and inducer of CYP3A4
DC74748	O4I4	O4I4 (compound 23) is a OCT4-inducing compound with metabolical stability.
DC74684	ZH8667	ZH8667 is a trace amine-associated receptor 1 (TAAR1)–Gs agonist.
DC74646	EB-PSMA-617	EB-PSMA-617 is an Evans blue-modified prostate-specific membrane antigen (PSMA) 617 ligand for making 177Lu-EB-PSMA, which is potential useful for Metastatic Castration-Resistant Prostate Cancer.