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FN1-8

  Cat. No.:  DC21050   Featured
Chemical Structure
1419258-63-1
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More than 5000 active chemicals with high quality for research!
Field of application
FN1-8 is a novel, synthetic small molecule that efficiently interferes with Gli/TAF9 interaction and downregulate Gli/TAF9-dependent transcriptional activity (at 15 uM); inhibits non-canonical Gli activation and acts downstream of the canonical Hh pathway; suppresses cancer cell proliferation in vitro and inhibits tumor growth in vivo.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1419258-63-1
Chemical Name: N-[(4-Hydroxyphenyl)methyl]-2,3,5-triphenyl-3,4-dihydropyrazole-4-carboxamide
Synonyms: N-(4-Hydroxybenzyl)-1,3,5-triphenyl-4,5-dihydro-1H-pyrazole-4-carboxamide;N-[(4-hydroxyphenyl)methyl]-2,3,5-triphenyl-3,4-dihydropyrazole-4-carboxamide
SMILES: O=C(C1C(C2C=CC=CC=2)=NN(C2C=CC=CC=2)C1C1C=CC=CC=1)NCC1C=CC(=CC=1)O
Formula: C29H25N3O2
M.Wt: 447.527706861496
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication: 1. Bosco-Clément G, et al. Oncogene. 2014 Apr 17;33(16):2087-97. 2. He B, et al. US Patent No. 7714014. 2010
Description: FN1-8 is a novel, synthetic small molecule that efficiently interferes with Gli/TAF9 interaction and downregulate Gli/TAF9-dependent transcriptional activity (at 15 uM); inhibits non-canonical Gli activation and acts downstream of the canonical Hh pathway; suppresses cancer cell proliferation in vitro and inhibits tumor growth in vivo.
Target: Gli
References: 1. Bosco-Clément G, et al. Oncogene. 2014 Apr 17;33(16):2087-97. 2. He B, et al. US Patent No. 7714014. 2010
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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