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| Cas No.: | 865363-93-5 |
| Chemical Name: | (2R,3S,5R)-5-(6-amino-2-fluoro-9H-purin-9-yl)-2-ethynyl-2-(hydroxymethyl)tetrahydrofuran-3-ol |
| Synonyms: | Islatravir;MK8591;EFdA |
| SMILES: | NC1=C(N=CN2[C@H]3C[C@@H]([C@@](O3)(C#C)CO)O)C2=NC(F)=N1 |
| Formula: | C12H12FN5O3 |
| M.Wt: | 293.25 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | MK-8591 is a potent anti-HIV-1 agent, acting as a nucleoside reverse transcriptase inhibitor, with EC50s of 0.068 nM, 3.1 nM and 0.15 nM for HIV-1 (WT), HIV-1 (M184V), HIV-1 (MDR), respectively. HIV Infection |
| Target: | HIV-1 (WT):0.068 nM (EC50) HIV-1 (MDR):0.15 nM (EC50) HIV-1 (M184V):3.1 nM (EC50) |
| In Vitro: | MK-8591 (4'Ed2FA) is a potent anti-HIV-1 agent, acting as a nucleoside reverse transcriptase inhibitor, with EC50s of 0.068 nM, 3.1 nM and 0.15 nM for HIV-1 (WT), HIV-1 (M184V), HIV-1 (MDR), respectively[1]. |
| References: | [1]. Ohrui H, et al. 2'-deoxy-4'-C-ethynyl-2-fluoroadenosine, a nucleoside reverse transcriptase inhibitor, is highly potent against all human immunodeficiency viruses type 1 and has low toxicity. Chem Rec. 2006;6(3):133-43. |
MSDS
COA
| LOT NO. | DOWNLOAD |
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| 2018-0101 |
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| 2018-0101 |
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| 2018-0101 |
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