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JNJ 39758979

  Cat. No.:  DC21177   Featured
Chemical Structure
1046447-90-8
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More than 5000 active chemicals with high quality for research!
Field of application
JNJ-39758979 is a selective, orally active, and high-affinity histamine H4 receptor antagonist with Kis of 12.5, 5.3, and 25 nM for human, mouse, and monkey histamine H4 receptor, respectively. JNJ-39758979 functionally antagonizes histamine-induced cAMP inhibition with a pA2 of 7.9 in transfected cells. JNJ-39758979 shows good anti-inflammatory and antipruritic activity.
Chemicals PropertiesBiological activity Related products COA MSDS Datasheet
Cas No.: 1046447-90-8
Chemical Name: JNJ-39758979
Synonyms: JNJ-39758979;jnj39758979;4-[(3R)-3-AMINOPYRROLIDIN-1-YL]-6-PROPAN-2-YLPYRIMIDIN-2-AMINE;JNJ 39758979 (JNJ-39758979;2-Pyrimidinamine, 4-[(3R)-3-amino-1-pyrrolidinyl]-6-(1-methylethyl)-;(R)-4-(3-aminopyrrolidin-1-yl)-6-isopropylpyrimidin-2-amine;agranulocytosis,histamine,JNJ-39758979,selective,toxicity,JNJ39758979,cAMP,inhibit,oral,Histamine Receptor,anti-inflammatory,Inhibitor,antipruritic,JNJ 39758979;MFCD28502028;MFCD28502028;JNJ-39758979, (-)-;JNJ-39758979, (-)-;4-((3R)-3-aminopyrrolidin-1-yl)-6-propan-2-ylpyrimidin-2-amine;4-((3R)-3-aminopyrrolidin-1-yl)-6-propan-2-ylpyrimidin-2-amine;CS-0020957;CS-0020957;BDBM50006789;BDBM50006789;1046447-90-8;1046447-90-8;JNJ 39758979 [WHO-DD];JNJ 39758979 [WHO-DD];2-Pyrimidinamine, 4-((3R)-3-amino-1-pyrrolidinyl)-6-(1-methylethyl)-;2-Pyrimidinamine, 4-((3R)-3-amino-1-pyrrolidinyl)-6-(1-methylethyl)-;4-[(3R)-3-aminopyrrolidin-1-yl]-6-propan-2-ylpyrimidin-2-amine;4-[(3R)-3-aminopyrrolidin-1-yl]-6-propan-2-ylpyrimidin-2-amine;GLXC-04851;GLXC-04851;WRB44790;WRB44790;MS-23237;MS-23237;SCHEMBL604514;SCHEMBL604514;JNJ 39758979;JNJ 39758979;(r)-4-(3-amino-pyrrolidin-1-yl)-6-isopropyl-pyrimidin-2-ylamine;(r)-4-(3-amino-pyrrolidin-1-yl)-6-isopropyl-pyrimidin-2-ylamine;4-[(3R)-3-aminopyrrolidin-1-yl]-6-isopropylpyrimidin-2-amine;4-[(3R)-3-aminopyrrolidin-1-yl]-6-isopropylpyrimidin-2-amine;HY-101189;HY-101189;GTPL8984;GTPL8984;UNII-5RV7T5BNMG;UNII-5RV7T5BNMG;Q27888282;Q27888282;JNJ-39758979 [WHO-DD];JNJ-39758979 [WHO-DD];4-[(3R)-3-aminopyrrolidin-1-yl]-6-(propan-2-yl)pyrimidin-2-amine;4-[(3R)-3-aminopyrrolidin-1-yl]-6-(propan-2-yl)pyrimidin-2-amine;AKOS030628488;AKOS030628488;5RV7T5BNMG;5RV7T5BNMG;CHEMBL3236549;CHEMBL3236549
SMILES: C1(N)=NC(C(C)C)=CC(N2CC[C@@H](N)C2)=N1
Formula: C11H19N5
M.Wt: 221.302061319351
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: A potent, selective, orally bioavailable histamine H4 receptor antagonist with Ki of 12.5 nM, >80-fold selectivity over other histamine receptors; shows dose-dependent activity in models of asthma and dermatitis, has good pharmacokinetics.AsthmaPhase 2 Clinical
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