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AEM1

  Cat. No.:  DC21399   Featured
Chemical Structure
1030123-90-0
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More than 5000 active chemicals with high quality for research!
Field of application
NRF2 inhibitor AEM1 is a specific small molecule inhibitor of Nrf2 transcriptional activity in cancer cells, shows no activity against a panel of >100 kinases (including isoforms of PI3K, AKT, and PKC).
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1030123-90-0
Chemical Name: 1-(2H-1,3-benzodioxol-5-yl)-N-[5-(4-fluorophenyl)-1H,4H-thieno[2,3-d]pyrimidin-4-ylidene]methanamine
SMILES: O1C2C=CC(CN=C3N=CNC4SC=C(C5C=CC(F)=CC=5)C3=4)=CC=2OC1
Formula: C20H14FN3O2S
M.Wt: 379.407466411591
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: NRF2 inhibitor AEM1 is a specific small molecule inhibitor of Nrf2 transcriptional activity in cancer cells, shows no activity against a panel of >100 kinases (including isoforms of PI3K, AKT, and PKC); broadly decreases the expression of Nrf2 controlled genes (HMOX1, GPX2), sensitizes A549 cells to various chemotherapeutic agents, and inhibits the growth of A549 cells in vitro and in vivo.
References: References 1. Bollong MJ, et al. ACS Chem Biol. 2015 Oct 16;10(10):2193-8. View Related Products by Target Keap1-Nrf2
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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