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NVP-2

  Cat. No.:  DC21430   Featured
Chemical Structure
1263373-43-8
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More than 5000 active chemicals with high quality for research!
Field of application
NVP-2 is a potent and selective ATP-competitive cyclin dependent kinase 9 (CDK9) probe, inhibits CDK9/CycT activity with an IC50 of 0.514 nM. NVP-2 displays inhibitory effcts on CDK1/CycB, CDK2/CycA and CDK16/CycY kinases with IC50 values of 0.584 µM, 0.7
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1263373-43-8
Chemical Name: 4-(((2'-chloro-5'-(((1R,4r)-4-(((R)-1-methoxypropan-2-yl)amino)cyclohexyl)amino)-[2,3'-bipyridin]-6-yl)amino)methyl)tetrahydro-2H-pyran-4-carbonitrile
Synonyms: NVP2;NVP 2;CDK9 inhibitor
SMILES: C[C@H](COC)NC1CCC(CC1)NC2=NC=C(C(=C2)C3=NC(=CC=C3)NCC4(CCOCC4)C#N)Cl
Formula: C27H37ClN6O2
M.Wt: 513.083
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: NVP-2 is a CDK9 inhibitor with an IC50 of 0.5 nM.
Target: CDK9:0.5 nM (IC50)
References: [1]. Wang J, et al. SnapShot: Kinase Inhibitors I. Mol Cell. 2015 May 21;58(4):708.e1.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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