OAT-177|CAS 1799548-33-6|DC Chemicals

Cas No.:	1799548-33-6
Chemical Name:	CC(C)CN(CCC1=CC=C(Cl)C=C1)C1CCN(CC1)C1=NC(N)=NN1
Synonyms:	GTPL9780;TQR1227;BDBM50243745;compound 7f [PMID: 29283260];CC(C)CN(CCC1=CC=C(Cl)C=C1)C1CCN(CC1)C1=NC(N)=NN1;1-(5-amino-1H-1,2,4-triazol-3-yl)-N-(4-chlorophenethyl)-N-isobutylpiperidin-4-amine;1-(3-amino-1H-1,2,4-triazol-5-yl)-N-[2-(4-chlorophenyl)ethyl]-N-(2-methylpropyl)piperidin-4-amine;4-?Piperidinamine, 1-?(3-?amino-?1H-?1,?2,?4-?triazol-?5-?yl)?-?N-?[2-?(4-?chlorophenyl)?ethyl]?-?N-?(2-?methylpropyl)?-
SMILES:	ClC1C=CC(=CC=1)CCN(CC(C)C)C1CCN(C2=NNC(N)=N2)CC1
Formula:	C₁₉H₂₉ClN₆
M.Wt:	376.926762342453
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

OAT-177 is a potent, selective, orally active acidic mammalian chitinase (AMCase) inhibitor with IC50 of 14 and 19 nM against human and mouse AMCas, respectively, >150-fold selectivity over mCHIT1; shows significant anti-inflammatory efficacy in HDM-induced allergic airway inflammation in mice at 30 mg/kg po, reduces inflammatory cell influx in the BALF and total IgE concentration in plasma.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

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