EG1|Pax2 inhibitor EG1|CAS 693241-54-2|DC Chemicals

Cas No.:	693241-54-2
Chemical Name:	2-(4-(2-methoxybenzamido)benzamido)benzoic acid
Synonyms:	Pax2 inhibitor EG1;EG-1;EG 1
SMILES:	C(C1C(NC(C2C=CC(NC(C3C(OC)=CC=CC=3)=O)=CC=2)=O)=CC=CC=1)(=O)O
Formula:	C₂₂H₁₈N₂O₅
M.Wt:	390.38
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	1. Grimley E, et al. ACS Chem Biol. 2017 Mar 17;12(3):724-734.

Description:

Pax2 inhibitor EG1 (EG1) is a potent, small molecule inhibitor of Pax2 mediated transcription activation, effectively blocks Pax2 activity and DNA binding with Kd of 1.35-1.5 uM; inhibits Pax2 mediated expression with IC50 of 10 uM, and inhibits proliferation of Pax2 positive renal and ovarian cancer cell lines but has little effect on Pax2 negative cancer cells; inhibits embryonic kidney development.

References:

References 1. Grimley E, et al. ACS Chem Biol. 2017 Mar 17;12(3):724-734. View Related Products by Target Other Targets

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2018-0101
2018-0101

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