RB-011|RB011;RB-11;RB11

Cas No.:	1425049-26-8
Chemical Name:	1-Methyl-1-[2-(4-octylphenyl)ethyl]pyrrolidin-1-ium
Synonyms:	1-Methyl-1-(4-octylphenethyl)pyrrolidin-1-ium;1-Methyl-1-[2-(4-octylphenyl)ethyl]pyrrolidin-1-ium
SMILES:	[N+]1(C)(CCC2C=CC(CCCCCCCC)=CC=2)CCCC1
Formula:	C₂₁H₃₆N
M.Wt:	302.517246246338
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

A small molecule that disrupt 14-3-3 dimers at low micromolar concentrations and induce rapid down-regulation of Raf-MAPK and PI3K-Akt signaling in Jurkat cells; ahs ED50 of 3 uM for apoptosis induction in Jurkat cells, inhibits A549 lung cancer cell growth in vitro and in vivo; exhibits a rounded morphology similar to that of 14-3-3ζ KO dermal fibroblasts, increasing signal flux through the ROCK pathway, impairing the ECM remodeling, and accelerating wound healing.

Cat. No.	Product name	Field of application
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