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STAT5 inhibitor 17f

  Cat. No.:  DC21703   Featured
Chemical Structure
2111834-61-6
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More than 5000 active chemicals with high quality for research!
Field of application
A novel potent, selective inhibitor of phosphorylation and transcriptional activity of STAT5, but not STAT3, AKT, or Erk1/2 phosphorylation.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 2111834-61-6
Chemical Name: Stat5-IN-2
Synonyms: STAT5-IN-2;1-(2-((1H-Indol-5-yl)oxy)ethyl)-4,4-dimethyl-6-(pyridin-3-yl)-1,2,3,4-tetrahydroquinoline
SMILES: O(C1C=CC2=C(C=CN2)C=1)CCN1C2C=CC(C3C=NC=CC=3)=CC=2C(C)(C)CC1
Formula: C26H27N3O
M.Wt: 397.51208615303
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: A novel potent, selective inhibitor of phosphorylation and transcriptional activity of STAT5, but not STAT3, AKT, or Erk1/2 phosphorylation; inhibits the growth of acute and chronic myeloid leukemia cells and the phosphorylation and transcriptional activity of STAT5; inhibits KU812 and K562 cell growth with IC50 of 9 and 5 uM, respectively, demonstrates highly potent antileukemic effect with minimal effects on bone marrow stromal cells.
Target: EC50: 9 μM (K562 cells), 5 μM (KU812 cells)[1]
References: [1]. Juen L, et al. New Inhibitor Targeting Signal Transducer and Activator of Transcription 5 (STAT5) Signaling in Myeloid Leukemias. J Med Chem. 2017 Jul 27;60(14):6119-6136.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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