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UU-T03

  Cat. No.:  DC21787   Featured
Chemical Structure
1586007-00-2
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More than 5000 active chemicals with high quality for research!
Field of application
UU-T03 is the ethyl ester derivative of UU-T02, which is a potent, selective inhibitor of β-catenin/Tcf4 interaction with Ki of 1.36 uM; exhibits growth inhibition of SW480 cells with IC50 of 10.77 uM; downregulates the transcription of AXIN2, LGR5, cyclin D1, and c-Myc in dose-dependent manners in SW480 cells.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1586007-00-2
Chemical Name: 5-ethyl 1-methyl ((S)-2-((S)-2-(2-(5-chloro-1H-indol-2-yl)acetamido)-3-(naphthalen-2-yl)propanamido)-4-ethoxy-4-oxobutanoyl)-L-glutamate
Synonyms: UU-T 03
SMILES: C(C)(O)(=O)[C@H](CCC(CC)(O)=O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CC1=CC2=C(C=CC(Cl)=C2)N1)CC1=CC=C2C(C=CC=C2)=C1)CC(OCC)=O
Formula: C37H41ClN4O9
M.Wt: 721.204
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication: 1. Huang Z, et al. ACS Chem Biol. 2014 Jan 17;9(1):193-201.
Description: UU-T03 is the ethyl ester derivative of UU-T02, which is a potent, selective inhibitor of β-catenin/Tcf4 interaction with Ki of 1.36 uM; exhibits growth inhibition of SW480 cells with IC50 of 10.77 uM; downregulates the transcription of AXIN2, LGR5, cyclin D1, and c-Myc in dose-dependent manners in SW480 cells.
References: References 1. Huang Z, et al. ACS Chem Biol. 2014 Jan 17;9(1):193-201. View Related Products by Target Beta-catenin
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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