AES-135|AES135;AES 135

Cas No.:	2361659-61-0
Chemical Name:	Chembl4520400
Synonyms:	4-(N-(4-(tert-butyl)benzyl)-2-((4-fluoro-N-((perfluorophenyl)methyl)phenyl)sulfonamido)acetamido)-N-hydroxybenzamide;BDBM50519452;Chembl4520400;AES-135
SMILES:	S(C1C([H])=C([H])C(=C([H])C=1[H])F)(N(C([H])([H])C1C(=C(C(=C(C=1F)F)F)F)F)C([H])([H])C(N(C1C([H])=C([H])C(C(N([H])O[H])=O)=C([H])C=1[H])C([H])([H])C1C([H])=C([H])C(=C([H])C=1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=O)(=O)=O
Formula:	C₃₃H₂₉F₆N₃O₅S
M.Wt:	693.6559
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

AES-135 (AES135) is a novel HDAC inhibitor that biochemically inhibits HDACs 3, 6, 8 and 11 with IC50 values of 190-1100 nM; exhibits selective in vitro cytotoxicity in low passage patient-derived pancreatic cancer cells even in the presence of cancer-associated fibroblast (CAF) cells; exhibits favourable in vivo properties such as metabolic stability in mouse hepatocytes and bioavailability in µM concentrations in NSG mice for >10 h (IP injection); shows cytotoxicity in multiple low-passage patient-derived pancreatic cancer cell lines with IC50 of 1-4 uM in monolayer proliferation-based assays, prolongs survival significantly in orthotopic murine model of pancreatic cancer.

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