PBT434|CAS 1232841-78-9|for Parkinson disease research

Cas No.:	1232841-78-9
Chemical Name:	5,7-dichloro-2-((ethylamino)methyl)-8-hydroxy-3-methylquinazolin-4(3H)-one hydrobromide
Synonyms:	PBT434\|PBT-434
SMILES:	N1C2=C(C(Cl)=CC(Cl)=C2O)C(=O)N(C)C=1CNCC.[HH0]Br
Formula:	C₁₂H₁₄BrCl₂N₃O₂
M.Wt:	383.067
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

PBT434 is a novel quinazolinone compound with effect of lowering cellular iron levels, prevents iron mediated neurodegeneration and α-synuclein toxicity in multiple models of Parkinson disease; inhibits iron-mediated redox activity and iron-mediated aggregation of α-synuclein, a protein that aggregates in the neuropathology; prevents loss of substantia nigra pars compacta neurons (SNpc), lowers nigral α-synuclein accumulation, and rescues motor performance in mice model of PD.

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