SB02024|SB-02024|Vps34 inhibitor|DC Chemicals

Cas No.:	2126737-28-6
Chemical Name:	SB02024
Synonyms:	SB02024;SB-02024;SB 02024
SMILES:	O=C1NC(N2[C@@H](C(F)(F)F)CCCC2)=CC(N3[C@H](C)COCC3)=C1
Formula:	C₁₆H₂₂F₃N₃O₂
M.Wt:	345.36
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	1. Dyczynski M, et al. Cancer Lett. 2018 Jul 25. pii: S0304-3835(18)30486-5.

Description:	SB02024 is a novel highly potent, selective, ATP competitive, orally active inhibitor of vacuolar protein sorting 34 (Vps34) with Kd of 1 nM, >1000 times selective towards other PI3K isoenzymes; SB02024 is also highly selective at 1 uM in the DiscoveRx ScanMax panel of 468 kinases; reduces the number of GFP-2xFYVE puncta with IC50 of 14 nM, induces a dose-dependent increase in levels of NCOA4 and p62; blocks autophagy in vitro and reduces xenograft growth of two breast cancer cell lines, MDA-MB-231 and MCF-7; also significantly potentiates cytotoxicity of Sunitinib and Erlotinib in MCF-7 and MDA-MB-231 in vitro.
Target:	Vps34 1 nM
References:	1. Dyczynski M, et al. Cancer Lett. 2018 Jul 25. pii: S0304-3835(18)30486-5.

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