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| Cas No.: | 1005883-72-6 |
| Chemical Name: | Z433927330 |
| Synonyms: | Z433927330;Ethyl 4-(3-(4-(1H-pyrazol-1-yl)benzyl)ureido)benzoate;ethyl 4-[(4-pyrazol-1-ylphenyl)methylcarbamoylamino]benzoate;ethyl 4-[({[4-(1H-pyrazol-1-yl)phenyl]methyl}carbamoyl)amino]benzoate;A937767 |
| SMILES: | O(C([H])([H])C([H])([H])[H])C(C1C([H])=C([H])C(=C([H])C=1[H])N([H])C(N([H])C([H])([H])C1C([H])=C([H])C(=C([H])C=1[H])N1C([H])=C([H])C([H])=N1)=O)=O |
| Formula: | C20H20N4O3 |
| M.Wt: | 364.3978 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Publication: | [1]. Z433927330, et al. Identification and characterization of potent and selective aquaporin-3 and aquaporin-7 inhibitors. J Biol Chem. 2019 May 3;294(18):7377-7387. |
| Description: | Z433927330 is a potent and selective inhibitor of Aquaporin-7 (AQP7), less potently inhibits AQP3 and AQPs9, with IC50s of ~0.2 µM, ~0.7 µM and ~1.1 µM for mAQP7, mAQP3 and mAQP9, respectively[1]. |
| Target: | IC50: ~0.2 µM (mAQP7), ~0.7 µM (mAQP3), ~1.1 µM (mAQP9)[1] |
| In Vitro: | Z433927330 inhibits glycerol permeability, with an IC50 of ~0.6 µM[1]. |
| References: | [1]. Z433927330, et al. Identification and characterization of potent and selective aquaporin-3 and aquaporin-7 inhibitors. J Biol Chem. 2019 May 3;294(18):7377-7387. |
MSDS
COA
| LOT NO. | DOWNLOAD |
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| 2018-0101 |
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| 2018-0101 |
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| 2018-0101 |
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