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TRi-1(TXNRD1 inhibitor 1)

  Cat. No.:  DC22309   Featured
Chemical Structure
246020-68-8
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More than 5000 active chemicals with high quality for research!
Field of application
TRi-1 (TXNRD1 inhibitor 1) is a potent, specific and irreversible inhibitor of cytosolic thioredoxin reductase 1 (TXNRD1) with anticancer potential, 5- to 10-fold higher specificity for TXNRD1 over TXNRD2.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 246020-68-8
Chemical Name: 2-((4-chlorophenyl)sulfonyl)-6-methoxy-3-nitropyridine
SMILES: O=[N+](C1=CC=C(OC)N=C1S(=O)(C2=CC=C(Cl)C=C2)=O)[O-]
Formula: C12H9ClN2O5S
M.Wt: 328.723
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: TRi-1 is a potent, specific and irreversible inhibitor of cytosolic thioredoxin reductase 1 (TXNRD1), with an IC50 of 12 nM. TRi-1 has little mitochondrial toxicity for anticancer therapy[1].
Target: IC50: 12 nM (TXNRD1)[1].
References: [1]. Stafford WC, et al. Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy. Sci Transl Med. 2018 Feb 14;10(428). pii: eaaf7444.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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