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Olorofim(F-901318)

  Cat. No.:  DC22391   Featured
Chemical Structure
1928707-56-5
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More than 5000 active chemicals with high quality for research!
Field of application
Olorofim (F901318) selectively inhibits fungal dihydroorotate dehydrogenase (DHODH), a key enzyme in the pyrimidine biosynthesis pathway. Olorofim (F901318). Olorofim exhibits excellent activity against A. fumigatus and other Aspergillus spp.
Chemicals PropertiesBiological activity Related products COA MSDS Datasheet
Cas No.: 1928707-56-5
Chemical Name: Olorofim
Synonyms: T34SH2H9HI;BCP25872;SB19827;F901318;1H-Pyrrole-2-acetamide, N-(4-(4-(5-fluoro-2-pyrimidinyl)-1-piperazinyl)phenyl)-1,5-dimethyl-alpha-oxo-3-phenyl-;2-(1,5-Dimethyl-3-phenyl-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2-oxo-acetamide;Unii-T34SH2H9HI;A.udagawae;A.tanneri;A.pseudoviridinutans;A.nidulans;A.subramanianii;A.fumisynnematus;A.fumigatus;HY-104029;HY-104029;BDBM50526857;BDBM50526857;D12505;D12505;F-901318 1928707-56-5;F-901318 1928707-56-5;CS-0025660;CS-0025660;CHEMBL4297609;CHEMBL4297609;Olorofim (USAN/INN);Olorofim (USAN/INN);2-(1,5-Dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-{4-[4-(5-fluoropyrimidin-2-yl)piperazin-1-yl]phenyl}-2-oxoacetamide;2-(1,5-Dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-{4-[4-(5-fluoropyrimidin-2-yl)piperazin-1-yl]phenyl}-2-oxoacetamide;Q27896127;Q27896127;Olorofim;Olorofim;EX-A7990;EX-A7990;1928707-56-5;1928707-56-5;G70521;G70521;2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2-oxoacetamide;2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2-oxoacetamide;OLOROFIM [WHO-DD];OLOROFIM [WHO-DD];F-901318;F-901318;olorofimum;olorofimum;1H-Pyrrole-2-acetamide, N-[4-[4-(5-fluoro-2-pyrimidinyl)-1-piperazinyl]phenyl]-1,5-dimethyl-alpha-oxo-3-phenyl-;1H-Pyrrole-2-acetamide, N-[4-[4-(5-fluoro-2-pyrimidinyl)-1-piperazinyl]phenyl]-1,5-dimethyl-alpha-oxo-3-phenyl-;F901318; F 901318; Olorofim;F901318; F 901318; Olorofim;UNII-T34SH2H9HI;UNII-T34SH2H9HI;TS-08516;TS-08516;DB15245;DB15245;AKOS040748340;AKOS040748340;OLOROFIM [INN];OLOROFIM [INN];GLXC-25141;GLXC-25141;SCHEMBL17767345;SCHEMBL17767345;2-(1,5-dimethyl-3-phenylpyrrol-2-yl)-N-{4-[4-(5-fluoropyrimidin-2-yl)piperazin-1-yl]phenyl}-2-oxoacetamide;2-(1,5-dimethyl-3-phenylpyrrol-2-yl)-N-{4-[4-(5-fluoropyrimidin-2-yl)piperazin-1-yl]phenyl}-2-oxoacetamide;OLOROFIM [USAN];Z3064247822;OLOROFIM [USAN];2-(1,5-dimethyl-3-phenylpyrrol-2-yl)-N-[4-[4-(5-fluoropyrimidin-2-yl)piperazin-1-yl]phenyl]-2-oxoacetamide;Z3064247822;Antifungal Agent F901318;2-(1,5-dimethyl-3-phenylpyrrol-2-yl)-N-[4-[4-(5-fluoropyrimidin-2-yl)piperazin-1-yl]phenyl]-2-oxoacetamide;Antifungal Agent F901318
SMILES: FC1C=NC(=NC=1)N1CCN(C2C=CC(=CC=2)NC(C(C2=C(C3C=CC=CC=3)C=C(C)N2C)=O)=O)CC1
Formula: C28H27FN6O2
M.Wt: 498.55
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: A novel antifungal agent that inhibits A. fumigatus DHODH with IC50 of 44 nM; shows little inhibition of human DHODH (>100 uM); displays excellent potency against a broad range of pathogenic filamentous and dimorphic fungi, including Penicillium spp., Coccidiodes immitis, H. capsulatum, Blastomyces dermatitidis, Fusarium spp., and the difficult-to-treat Scedosporium spp.Fungal InfectionPhase 2 Clinical
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