LY-487379| CAS 353231-17-1|DC Chemicals

Cas No.:	353231-17-1
Chemical Name:	2,2,2-Trifluoro-N-[4-(2-methoxyphenoxy)phenyl]-N-(3-pyridinylmethyl)ethanesulfonamide
Synonyms:	LY487379;LY-487379;LY 487379
SMILES:	FC(F)(F)CS(N(C1C=CC(OC2C=CC=CC=2OC)=CC=1)CC1=CC=CN=C1)(=O)=O
Formula:	C₂₁H₁₉F₃N₂O₄S
M.Wt:	452.446
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	1. Johnson MP, et al. J Med Chem. 2003 Jul 17;46(15):3189-92. 2. Schaffhauser H, et al. Mol Pharmacol. 2003 Oct;64(4):798-810. 3. Poisik O, et al. Neuropharmacology. 2005;49 Suppl 1:57-69.

Description:

LY-487379 is a potent, selective positive allosteric modulator of mGluR2 (EC50=0.27 uM) without activity at mGluR3; shows no intrinsic agonist or antagonist activity at hmGluR2, markedly potentiates glutamate-stimulated [35S]GTPgammaS binding at hmGluR2; potentiates synaptically evoked mGluR2 responses in rat hippocampal slices, modulates excitatory synaptic transmission in the rat globus pallidus.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101
2018-0101

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LY487379