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Sappanone A

  Cat. No.:  DC22453   Featured
Chemical Structure
102067-84-5
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More than 5000 active chemicals with high quality for research!
Field of application
A homoisoflavanone found in Caesalpinia sappan, a potent, selective IMPDH2 inhibitor that covalently binds to Cys140 with Kd of 3.944 nM, almost 10 times lower than the Kd of binding to IMPDH1.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 102067-84-5
Chemical Name: (3E)-3-(3,4-Dihydroxybenzylidene)-7-hydroxy-2,3-dihydro-4H-chromen-4-one
SMILES: OC1C=C2C(C(=O)/C(=C\C3C=CC(O)=C(O)C=3)/CO2)=CC=1
Formula: C16H12O5
M.Wt: 284.26
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Sappanone A is a homoisoflavanone which exhibits anti-inflammatory effects via modulation of Nrf2 and NF-κB. Sappanone can attenuate allergic airway inflammation in Ovalbumin-induced asthma[1].
References: [1]. Lee S, et, al. Sappanone A exhibits anti-inflammatory effects via modulation of Nrf2 and NF-κB. Int Immunopharmacol. 2015 Sep;28(1):328-36. [2]. Liu X, et, al. Sappanone A Attenuates Allergic Airway Inflammation in Ovalbumin-Induced Asthma. Int Arch Allergy Immunol. 2016;170(3):180-6.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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