Cas No.: | 1094067-13-6 |
Chemical Name: | 1-Propanol, 2-[ethyl[[5-[[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino]-3-isothiazolyl]methyl]amino]-2-methyl-, hydrochloride (1:x) |
SMILES: | Cl.CC1N/C(=N\C2SN=C(CN(C(CO)(C)C)CC)C=2)/C2N(C(C3=CNN=C3)=CN=2)C=1 |
Formula: | C20H27ClN8Os |
M.Wt: | 462.9994 |
Purity: | >98% |
Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
Description: | A potent, picomolar, dual inhibitor of Aurora A and B with IC50 of 0.02 and 0.03 nM, respectively; shows improved cell potency (phos-HH3 inhibition IC50=25 nM) and intrinsic aqueous solubility (11.4 mM); emonstrated efficacy and target engagement in human tumor xenograft mouse models. |