Cas No.: | 193282-45-0 |
Chemical Name: | 1-(4-(3,3,3-triphenylpropoxy)phenethyl)guanidine |
Synonyms: | RWJ 49815;RWJ49815 |
Formula: | C30H31N3O |
M.Wt: | 449.598 |
Purity: | >98% |
Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
Description: | A potent bactericidal agent that inhibits the KinA autophosphorylation with IC50 of 1.6 uM; inhibits the autophosphorylation of kinase A of the KinA-Spo0F two-component signal transduction system in vitro; suppresses growth of MRSA, vancomycin-resistant Enterococcus faecium, and penicillin-resistant Streptococcus pneumoniae (MICs=1-2 ug/ml); exhibits reduced resistance emergence in a laboratory passage experiment compared with quinolone and ciprofloxacin. |