Cas No.: | 19881-70-0 |
Chemical Name: | (Z)-3-chloro-2,3-bis(4-methoxyphenyl)acrylaldehyde |
SMILES: | COC1C=CC(/C(=C(/C2C=CC(OC)=CC=2)\C=O)/Cl)=CC=1 |
Formula: | C17H15ClO3 |
M.Wt: | 302.75 |
Purity: | >98% |
Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
Description: | A potent, selective inhibitor of p300 histone acetyltransferase (IC50=4.2 uM); displays >10-fold selectivity over other histone acetyltransferases; inhibits Wnt3a-inducible TOPFLASH-luciferase activity with IC50 of 1.5 uM, exhibits remarkable specificity toward β-catenin-1 function and selectively blocks the Wnt signal required for ventral development; robustly and selectively kills cancer cells that harbor Wnt-activating mutations. |