R243| CAS 688352-84-3|DC Chemicals

Cas No.:	688352-84-3
Chemical Name:	7,8-Dihydro-7-[2-(tricyclo[3.3.1.1(3,7)]dec-1-yloxy)ethyl]-6H-1,3-dioxolo[4,5-g][1,3]benzoxazine
Synonyms:	R-243;R 243
SMILES:	N1(CCOC2(C3)CC4CC3CC(C4)C2)COC5=CC(OCO6)=C6C=C5C1
Formula:	C₂₁H₂₇NO₄
M.Wt:	357.45
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

R243 is a potent, small molecule CCR8 antagonist that inhibits CCR8 signaling and chemotaxis, inhibits CCL1-induced Ca2+ flux and CCL1-driven peritoneal macrophages aggregation at 0.2 uM; attenuated secretion of TNF-α, IL-6, and most strikingly IL-10 from WT PMφ (peritoneal macrophages), but not BMMφ (bone marrow-derived macrophages); shows suppressed c-JNK activity and NF-κB signaling after LPS treatment, suppresses LPS-induced cytokine secretion; attenuates peritoneal adhesions in vivo in CCR8-/- mice, also prevents hapten-induced colitis.

References:

References 1. Oshio T, et al. PLoS One. 2014 Apr 8;9(4):e94445. 2. Berenguer J, et al. J Extracell Vesicles. 2018 Mar 13;7(1):1446660. View Related Products by Target Chemokine Receptor (CCR and CXCR)

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101
2018-0101
2018-0101

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