JNJ-46778212| CAS 1363281-27-9

Cas No.:	1363281-27-9
Chemical Name:	JNJ-46778212
Synonyms:	JNJ-46778212;VU0409551;VU 0409551;(4-fluorophenyl)(2-(phenoxymethyl)-6,7-dihydrooxazolo[5,4-c]pyridin-5(4H)-yl)methanone;(4-fluorophenyl)-[2-(phenoxymethyl)-6,7-dihydro-4H-[1,3]oxazolo[5,4-c]pyridin-5-yl]methanone;5-(4-fluorobenzoyl)-2-(phenoxymethyl)-4H,5H,6H,7H-[1,3]oxazolo[5,4-c]pyridine;JNJ46778212;JNJ 46778212;GTPL11437;BDBM50518042;SB19108;[6,7-Dihydro-2-(phenoxymethyl)o
SMILES:	FC1C=CC(=CC=1)C(N1CC2=C(CC1)N=C(COC1C=CC=CC=1)O2)=O
Formula:	C₂₀H₁₇FN₂O₃
M.Wt:	352.358988523483
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

A potent, selective, CNS penetrant and orally bioavailable mGlu5 positive allosteric modulator that potentiates human mGlu5 with EC50 of 260 nM; potentiates DHPG-induced long-term depression and induces calcium mobilization and ERK phosphorylation, does not potentiate mGlu5 modulation of NMDA receptor currents nor NMDA receptor-dependent long-term potentiation; demonstrates in vivo efficacy in multiple preclinical models o schizophrenia, coupled with good DMPK profile and acceptable therapeutic window.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
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