BRD5814| CAS 1953181-29-7

Cas No.:	1953181-29-7
Chemical Name:	Chembl4467883
Synonyms:	BRD5814;4-(4-Chlorophenoxy)-4-methyl-1-(2-(2-(trifluoromethyl)phenoxy)ethyl)piperidine;BDBM50518039;ClC1=CC=C(OC2(CCN(CC2)CCOC2=C(C=CC=C2)C(F)(F)F)C)C=C1;Chembl4467883
SMILES:	ClC1C=CC(=CC=1)OC1(C)CCN(CCOC2C=CC=CC=2C(F)(F)F)CC1
Formula:	C₂₁H₂₃ClF₃NO₂
M.Wt:	413.861035585403
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

BRD5814 is a potent, selective, highly brain penetrant β-arrestin biased dopamine D2 receptor (D2R) antagonist with Ki of 0.27 uM; BRD5814 strongly diminish D2R/β-arrestin signaling (EC50=0.54 uM) without affecting D2R/Gαi signaling; BRD5814 demonstrates good target engagement via PET imaging, achieving efficacy in an amphetamine-induced hyperlocomotion mouse model with strongly reduced motoric side effects in a rotarod performance test.

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