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| Cas No.: | 259218-28-5 |
| Chemical Name: | N(2)-[(2,2-diphenylethoxy)acetyl]-L-arginine |
| Synonyms: | SB-290157;SB290157 |
| SMILES: | C1(C(C2=CC=CC=C2)COCC(N[C@H](C(O)=O)CCCNC(=N)N)=O)=CC=CC=C1 |
| Formula: | C22H28N4O4 |
| M.Wt: | 412.49 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | A potent, selective nonpeptide antagonist of anaphylatoxin C3a receptor (C3aR) with IC50 of 200 nM; does not antagonize the C5aR or 5 other chemotactic GPCRs on human neutrophils; blocks C3a-induced C3aR internalization and C3a-induced Ca(2+) mobilization in RBL-C3aR cells and human neutrophils with IC50 of 27.7 and 28 nM, respectively; also inhibits C3a-induced Ca2+ mobilization of mouse and guinea pig C3aRS with IC50 of 7 and 12.5 nM, respectively; potently inhibits C3a-mediated ATP release from guinea pig platelets and inhibits C3a-induced potentiation of the contractile response to field stimulation of perfused rat caudal artery, demonstrates antiinflammatory activity in animal models. |