Cas No.: | 854165-96-1 |
Chemical Name: | 2-(dimethylamino)-5-isobutyramido-N-(1-phenylethyl)benzamide |
Synonyms: | RY 796;RY-796 |
Formula: | C21H27N3O2 |
M.Wt: | 353.466 |
Purity: | >98% |
Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
Description: | A novel potent, selective Kv2 channel inhibitor that potently inhibits Kv2.1 and Kv2.2 with IC50 of 0.14 and 0.09 uM, respectively; shows no significant activity against Kv1.2 and Kv7.1, and Cav channels; enhances GSIS in isolated wild-type (WT) mouse and human islets, but not in islets from Kv2.1(-/-) mice, enhances somatostatin release in isolated human and mouse islets. |