Cas No.: | 745055-91-8 |
Chemical Name: | (S)-1-(2-Amino-2-carboxyethyl)-3-(2-carboxybenzyl)pyrimidine-2,4-dione |
Synonyms: | UBP-302;UBP302; (S)-UBP 296 |
SMILES: | NC(C(O)=O)CN1C=CC(=O)N(CC2C=CC=CC=2C(O)=O)C1=O |
Formula: | C15H15N3O6 |
M.Wt: | 333.3 |
Purity: | >98% |
Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
Description: | A potent, and selective GluR5-subunit containing kainate receptor antagonist with Kd of 402 nM; displays about 260-fold selectivity over AMPA receptors, 90-fold selectivity over recombinant human GLUK6- and GLUK2-containing kainate receptors and has little or no action at NMDA or group I mGlu receptors; blocks kainate receptor-mediated LTP induction in rat hippocampal mossy fibers; also protects against soman-induced seizures and neuronal degeneration in vivo. |