Cas No.: | |
Chemical Name: | 2-((E)-3-isopropyl-5-((E)-3-oxo-3-(p-tolyl)prop-1-en-1-yl)benzylidene)-N-phenylhydrazine-1-carboxamide |
Synonyms: | CS11;CS 11 |
Formula: | C27H27N3O2 |
M.Wt: | 425.532 |
Purity: | >98% |
Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
Description: | A novel small molecule inhibitor that inhibits PP2A and β-catenin interaction by selectively engaging PR55α binding site (Kd=45 pM); diminishes the expression of active β-Catenin and its target proteins c-Myc and cyclin D1, promotes robust E-Cadherin upregulation on the cell surface and increases β-Catenin-E-Cadherin association; shows activity both in vivo tumor growth and metastasis |