PF-06446846| CAS 1632250-49-7

Cas No.:	1632250-49-7
Chemical Name:	N-(3-Chloropyridin-2-yl)-N-[(3R)-piperidin-3-yl]-4-(triazolo[4,5-b]pyridin-3-yl)benzamide
Synonyms:	(R)-4-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)-N-(3-chloropyridin-2-yl)-N-(piperidin-3-yl)benzamide;BDBM200332;US9227956, 16;N-(3-chloropyridin-2-yl)-N-[(3R)-piperidin-3-yl]-4-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)benzamide;N-(3-chloropyridin-2-yl)-N-[(3R)-piperidin-3-yl]-4-(triazolo[4,5-b]pyridin-3-yl)benzamide;PF-06446846
SMILES:	ClC1=CC=CN=C1N(C(C1C=CC(=CC=1)N1C2C(=CC=CN=2)N=N1)=O)[C@H]1CNCCC1
Formula:	C₂₂H₂₀ClN₇O
M.Wt:	433.893502235413
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

PF-06446846 (PF-6446846) is a potent, highly selective inhibitor of PCSK9 translation with IC50 of 0.3 uM for inhibition the secretion of PCSK9 by Huh7 cells; shows no general effect on the secreted and intracellular proteome; induces the ribosome to stall around codon 34, mediated by the sequence of the nascent chain within the exit tunnel; reduces plasma PCSK9 and total cholesterol levels in rats following oral dosing.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

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