DDX3-IN-16d| CAS 1919828-83-3

Cas No.:	1919828-83-3
Chemical Name:	Ddx3-IN-1
Synonyms:	DDX3-IN-1;1-[4-(4-methyltriazol-1-yl)phenyl]-3-(o-tolyl)urea;CC=1N=NN(C=1)C1=CC=C(C=C1)NC(=O)NC1=C(C=CC=C1)C
SMILES:	O=C(NC1C=CC=CC=1C)NC1C=CC(=CC=1)N1C=C(C)N=N1
Formula:	C₁₇H₁₇N₅O
M.Wt:	307.349782705307
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

A small molecule inhibitor (IC50=0.3 uM) of DEAD-box polypeptide 3 (DDX3), a human host factor required for the replication of several DNA and RNA viruses; shows a broad spectrum of antiviral activity with EC50 of 0.97-16.5 uM (HIV, HCV, DENV, and WNV), retaines full activity against HIV drug-resistant strains (EC50<1 uM); exhibts a good safety profile and bioavailability in rats.

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