NS3861 fumarate| CAS 216853-60-0|DC Chemicals

Cas No.:	216853-60-0
Chemical Name:	3-(3-Bromothiophen-2-yl)-8-methyl-8-azabicyclo[3.2.1]oct-2-ene;(E)-but-2-enedioic acid
Synonyms:	NS 3861;3-(3-Bromo-2-thienyl)-8-methyl-8-azabicyclo[3.2.1]oct-2-ene fumarate;3-(3-Bromothiophen-2-yl)-8-methyl-8-azabicyclo[3.2.1]oct-2-ene fumarate;3-(3-Bromo-2-thienyl)-8-methyl-8-azabicyclo[3.2.1]oct-2-ene(2E)-2-Butenedioate;3-(3-Bromothiophen-2-yl)-8-methyl-8-azabicyclo[3.2.1]oct-2-ene;(E)-but-2-enedioic acid
SMILES:	BrC1C([H])=C([H])SC=1C1=C([H])C2([H])C([H])([H])C([H])([H])C([H])(C1([H])[H])N2C([H])([H])[H].O([H])C(/C(/[H])=C(\[H])/C(=O)O[H])=O
Formula:	C₁₆H₁₈BrNO₄S
M.Wt:	400.2874
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

A potent, subtype-selective α3β4 nAChR partial agonist with Ki of 0.62 nM; selectively activates receptors containing β4- but not β2-subunits, shows no efficacy at α4β2 receptors and only marginal efficacy at α4β4 receptors expressed in oocytes; enhances fecal pellet expulsion in a dose-dependent manner in mice that received long-term, but not short-term, morphine treatment.

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