Cas No.: | 2138-34-3 |
Chemical Name: | 1-(4-bromophenyl)-3-(dimethylamino)propan-1-one |
Synonyms: | Aldi6 |
SMILES: | CN(C)CCC(=O)C1=CC=C(Br)C=C1 |
Formula: | C11H14BrNO |
M.Wt: | 256.143 |
Purity: | >98% |
Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
Description: | A novel small molecule ALDH inhibitor with IC50 of 600 nM, 800 nM and 1000 nM for ALDH1A1, ALDH2, and ALDH3A1, respectively; decreases SCC4 cells viability, sensitizes HNSCC cells to cisplatin; the combination of Aldi-6 and cisplatin causes a greater reduction in tumor burden in vivo than cisplatin alone. |