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| Cas No.: | 292168-90-2 |
| Chemical Name: | (5E)-5-(5-Bromo-2-hydroxy-3-methoxybenzylidene)-2-thioxoimidazolidin-4-one |
| Synonyms: | 5-(5-Bromo-2-hydroxy-3-methoxybenzylidene)-2-thioxoimidazolidin-4-one;(5E)-5-(5-bromo-2-hydroxy-3-methoxybenzylidene)-2-thioxoimidazolidin-4-one;STL418592;(E/Z)-IT-603 |
| SMILES: | BrC1C([H])=C(C(=C(C=1[H])/C(/[H])=C1\C(N([H])C(N\1[H])=S)=O)O[H])OC([H])([H])[H] |
| Formula: | C11H9BrN2O3S |
| M.Wt: | 329.1698 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | A small molecule inhibitor of the NF-κB family member c-Rel with IC50 of 3 uM in EMSA assays; inhibits human diffuse large B-cell lymphoma (DLBCL) cell line with IC50 of 18 uM, binds c-Rel directly and changes the conformation of the protein, inhibiting DNA binding and transcriptional activity. |
| References: | References 1. Shono Y, et al. Cancer Discov. 2014 May;4(5):578-91. View Related Products by Target NF-κB |
MSDS
COA
| LOT NO. | DOWNLOAD |
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| 2018-0101 |
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| 2018-0101 |
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| 2018-0101 |
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