EN460| CAS 496807-64-8

Cas No.:	496807-64-8
Chemical Name:	EN460
Synonyms:	EN460;EN-460
SMILES:	FC(F)(F)C1=NN(C2=CC(C(O)=O)=C(Cl)C=C2)C(/C1=C\C3=CC=C(C4=CC=CC=C4)O3)=O
Formula:	C₂₂H₁₂ClF₃N₂O₄
M.Wt:	460.789895057678
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

EN460 is a specific mall molecule inhibitor of endoplasmic reticulum oxidation 1 (ERO1), interacts selectively with the reduced, active form of ERO1α and prevents its reoxidation (IC50=1.9 uM); promotes signaling in the unfolded protein response and precondition cells against severe ER stress, shows a dose response effect on the embryos with a dose of 10 uM being significantly lethal during early embryonic development.

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