Cas No.: | 37988-18-4 |
Chemical Name: | 1,3,5-Benzenetricarboxamide, N1,N3,N5-tris(2-hydroxyethyl)- |
Synonyms: | LM 22A4 |
SMILES: | OCCNC(C1C=C(C(NCCO)=O)C=C(C(NCCO)=O)C=1)=O |
Formula: | C15H21N3O6 |
M.Wt: | 339.3438 |
Purity: | >98% |
Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
Description: | A small molecule BDNF mimetic that act as a direct and specific partial agonist of TrkB (EC50=200-500 pM), but not p75; activates TrkB signaling and prevents neuronal degeneration in rodents; rescues TrkB phosphorylation deficits and improves respiratory function in a mouse model of Rett syndrome. |