Cas No.: | 1354742-60-1 |
Chemical Name: | 7-(furan-2-yl)-2-hydroxyisoquinoline-1,3(2H,4H)-dione |
Synonyms: | YLC 2-155;YLC2155 |
Formula: | C13H9NO4 |
M.Wt: | 243.22 |
Purity: | >98% |
Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
Description: | YLC2-155 is a novel potent HIV-1 reverse transcriptase (RT) inhibitor that inhibits both polymerase (IC50=2.6 uM) and RNase H function (IC50=0.65 uM) of RT; binds at the RNase H (RNH)-active site in multiple conformations; demonstrates inhibition of fully infectious HIV-1 (strain NL4-3) with EC50 of 6.7 uM in cell-based assays. |