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BI-3812

  Cat. No.:  DC23310   Featured
Chemical Structure
2166387-64-8
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More than 5000 active chemicals with high quality for research!
Field of application
BI-3812 is potent and efficacious BCL6 inhibitor, inhibiting the BTB domain of BCL6, with an IC50 of ≤3 nM; BI-3812 has antitumor activity.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 2166387-64-8
Chemical Name: 1-[5-Chloro-4-[[8-methoxy-1-methyl-3-[2-(methylamino)-2-oxoethoxy]-2-oxoquinolin-6-yl]amino]pyrimidin-2-yl]-N,N-dimethylpiperidine-4-carboxamide
Synonyms: BI-3812;1-(5-chloro-4-((8-methoxy-1-methyl-3-(2-(methylamino)-2-oxoethoxy)-2-oxo-1,2-dihydroquinolin-6-yl)amino)pyrimidin-2-yl)-N,N-dimethylpiperidine-4-carboxamide;BCP31903;s8735;SB40386;BI 3812; BI3812;1-[5-Chloro-4-[[8-methoxy-1-methyl-3-[2-(methylamino)-2-oxoethoxy]-2-oxoquinolin-6-yl]amino]pyrimidi
SMILES: ClC1=C([H])N=C(N=C1N([H])C1=C([H])C(=C2C(C([H])=C(C(N2C([H])([H])[H])=O)OC([H])([H])C(N([H])C([H])([H])[H])=O)=C1[H])OC([H])([H])[H])N1C([H])([H])C([H])([H])C([H])(C(N(C([H])([H])[H])C([H])([H])[H])=O)C([H])([H])C1([H])[H]
Formula: C26H32ClN7O5
M.Wt: 558.0292
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: BI-3812 is potent and efficacious BCL6 inhibitor, inhibiting the BTB domain of BCL6, with an IC50 of ≤3 nM; BI-3812 has antitumor activity.
Target: IC50: ≤3 nM (BCL6 BTB)[1]
In Vivo: BI-3812 is a BCL6 inhibitor, with an IC50 of ≤3 nM. BI-3812 shows an IC50 of 40 nM for the cellular BCL6[1].
References: [1]. Kerres N, et al. Chemically Induced Degradation of the Oncogenic Transcription Factor BCL6. Cell Rep. 2017 Sep 19;20(12):2860-2875.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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