Cas No.: | 191421-10-0 |
Chemical Name: | (2R,3R,5R)-2-(hydroxymethyl)-5-(5-nitro-1H-indol-1-yl)tetrahydrofuran-3-ol |
Synonyms: | 5-nitro-indolyl-2'-deoxynucleoside |
Formula: | C13H14N2O5 |
M.Wt: | 278.264 |
Purity: | >98% |
Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
Description: | 5-NIdR (5-nitro-indolyl-2'-deoxynucleoside) is a non-natural nucleotide produces cytostatic and cytotoxic effects against human leukemia cells by altering cell-cycle progression; efficiently and selectively inhibits the replication of DNA lesions, synergizes with temozolomide to increase apoptosis of tumor cells; causes complete tumor regression combined with Temozolomide in murine xenograft model of glioblastoma |