ML381| CAS 1623481-80-0

Cas No.:	1623481-80-0
Chemical Name:	ML381 (VU0488130)
Synonyms:	ML381 (VU0488130);ML381(VU0488130);ML381;ML381(VU0488130) ?5-[(3-Acetylphenoxy)methyl]-N-methyl-N-[(1S)-1-pyridin-2-ylethyl]-1,2-oxazole-3-carboxamide;3-Isoxazolecarboxamide, 5-[(3-acetylphenoxy)methyl]-N-methyl-N-[(1S)-1-(2-pyridinyl)ethyl]-;ML381 (VU0488130) Fumarate;VU 0488130;VU0488130;VU-0488130
SMILES:	O1C(COC2=CC=CC(C(C)=O)=C2)=CC(C(N(C)[C@H](C2=NC=CC=C2)C)=O)=N1
Formula:	C₂₁H₂₁N₃O₄
M.Wt:	379.420
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

ML381 (VU0488130) is a highly mAChR subtype selective M5 orthosteric antagonist with IC50/Ki of 450/340 nM for hM5, has no inhibitory activity on hM1-4 (IC50>30 uM); exhibits good DMPK properties and CNS penetration (B:P ratio of 0.58) to support both in vitro and in vivo studies.

MSDS

COA

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2018-0101

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