Cas No.: | 148-53-8 |
Chemical Name: | 2-Hydroxy-3-methoxybenzaldehyde |
Synonyms: | C29L;ortho-Vanillin |
SMILES: | COC1C=CC=C(C=O)C=1O |
Formula: | C8H8O3 |
M.Wt: | 152.15 |
Purity: | >98% |
Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
Description: | o-vanillin (C29L;ortho-Vanillin) is the C29 derivative that blocks hTLR2/1 and hTLR2/6 signaling with IC50 of 24.2 uM and 37.2 uM in NF-κB reporter assay in HEK293T cells, respectivel;y; significantly blocks IL-12 p40 and TNF-α liver cytokine mRNA and serum protein, inhibits TLR2/1-induced proinflammatory cytokines in mice; is more soluble in water than C29. |