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PF-0346275

  Cat. No.:  DC23599   Featured
Chemical Structure
1173239-39-8
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More than 5000 active chemicals with high quality for research!
Field of application
PF-0346275 is a potent, selective, orally available GlyT1 inhibitor with Ki of 11.6 nM, without activity against GlyT2 (IC50>10 uM).
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1173239-39-8
Chemical Name: N-(3-chloro-4-fluorobenzyl)-1-methyl-N-(((1R,5S,6r)-3-methyl-3-azabicyclo[3.1.0]hexan-6-yl)methyl)-1H-imidazole-4-carboxamide
Synonyms: PF-0346275;PF 0346275;PF0346275
SMILES: CN1C[C@@H]2[C@H](C1)C2CN(CC3=CC(=C(C=C3)F)Cl)C(=O)C4=CN(C=N4)C
Formula: C19H22ClFN4O
M.Wt: 376.86
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: A potent, selective, orally available GlyT1 inhibitor with Ki of 11.6 nM, without activity against GlyT2 (IC50>10 uM); demonstrates potent activity in elevating CSF levels of glycine in vivo (ED200, 3.5 mg/kg).
References: References 1. Lowe JA 3rd, et al. Bioorg Med Chem Lett. 2009 Jun 1;19(11):2974-6. 2. Yamamoto S, et al. Chem Pharm Bull (Tokyo). 2016;64(11):1630-1640. View Related Products by Target Glycine Transporter (GlyT)
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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