NAB-14| NAB14|CAS 1237541-73-9|DC Chemicals

Cas No.:	1237541-73-9
Chemical Name:	4-((1H-indol-7-yl)carbamoyl)phenyl diethylcarbamate
Synonyms:	NAB14,NAB 14
SMILES:	C(OC1=CC=C(C(=O)NC2C3=C(C=CC=2)C=CN3)C=C1)(=O)N(CC)CC
Formula:	C₂₀H₂₁N₃O₃
M.Wt:	351.406
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

NAB-14 is a potent, selective negative allosteric modulator of GluN2C/2D-containing NMDA receptors with IC50 of 580 nM, >800-fold selective over GluN2A/GluN2 receptors; inhibits triheteromeric (GluN1/GluN2A/GluN2C) NMDARs with modestly reduced potency and efficacy compared to diheteromeric (GluN1/GluN2C/GluN2C) receptors; inhibits GluN2D-mediated synaptic currents in rat subthalamic neurons and mouse hippocampal interneurons, but has no effect on synaptic transmission in hippocampal pyramidal neurons.

References:

References 1. Swanger SA, et al. ACS Chem Neurosci. 2018 Feb 21;9(2):306-319. View Related Products by Target iGluR

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

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