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PF-06761281

  Cat. No.:  DC23623   Featured
Chemical Structure
1854061-19-0
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More than 5000 active chemicals with high quality for research!
Field of application
A potent, selective sodium-coupled citrate transporter (NaCT or SLC13A5) with IC50 of 0.51 uM, >20-fold selectivity over NaDC1 and NaDC3.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1854061-19-0
Chemical Name: (2R)-2-Hydroxy-2-[2-(2-methoxy-5-methyl-3-pyridinyl)ethyl]-butanedioic acid
Synonyms: (2R)-2-Hydroxy-2-[2-(2-methoxy-5-methyl-3-pyridinyl)ethyl]-butanedioic acid;BDBM50149244;SB19767;J3.605.617G;(R)-2-Hydroxy-2-[2-(2-methoxy-5-methyl-3-pyridinyl)ethyl]succinic acid
SMILES: O([H])[C@@](C(=O)O[H])(C([H])([H])C(=O)O[H])C([H])([H])C([H])([H])C1=C(N=C([H])C(C([H])([H])[H])=C1[H])OC([H])([H])[H]
Formula: C13H17NO6
M.Wt: 283.2772
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: A potent, selective sodium-coupled citrate transporter (NaCT or SLC13A5) with IC50 of 0.51 uM, >20-fold selectivity over NaDC1 and NaDC3; demonstrates dose-dependent inhibition of radioactive [(14)C]citrate uptake in liver and kidney in vivo, reduces fasting plasma glucose concentrations with suitable in vivo pharmacokinetic profile.
References: References 1. Huard K, et al. J Med Chem. 2016 Feb 11;59(3):1165-75. 2. Rives ML, et al. Mol Pharmacol. 2016 Dec;90(6):766-774. View Related Products by Target Sodium-coupled Citrate Transporter (NaCT,SLC13A5)
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
2018-0101
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